Can Omega-3 Fish Oil Help You Lose Weight?

Over the years, I’ve often heard people say, “I’m not sure about taking a fish oil supplement…won’t omega-3 fatty acids make me fat?”

Unfortunately, the notion that all fat is bad persists. But today, it’s been well proven that it’s which types of fat you eat, not all fat in general.

Does fish oil help you lose weight? Does it make you gain weight? Let’s find out. We’ll take a closer look at why omega-3 fatty acids in fish oil play important roles in regulating our metabolism and may also influence our weight.

The Connection Between Omega-3s & Weight Management

In the United States today, one in five people struggle with obesity. Obesity is defined as having abnormal fat accumulation that poses health risks.

Obesity is a complex, multi-factorial issues. In other words, there are many causes for it, and it doesn’t have a simple solution. But one identified risk factor for obesity is having a high omega-6 to omega-3 ratio.

If that sounds complex, bear with me. It’s more intuitive than you might think.

How the Omega-6: Omega-3 Ratio Influences Weight Gain

Omega-6 represents a family of fats. Typically, you’ll find lots of omega-6s in vegetable oils, like the corn and soybean oil that make many of our processed foods. Omega-6s saturate most of the foods you know aren’t great for your health, like cookies, chips, and fried foods. Omega-3s, on the other hand, are largely lacking from the normal American diet. You mostly find omega-3s in things like fatty fish, flax and chia seeds, and certain types of nuts. Many people take fish oil supplements to increase their omega-3 intake.

Having a high omega-6 to omega-3 ratio means you’re consuming too much omega-6 and too little omega-3 from your diet. And today, having an out-of-whack ratio has become the norm.

Our ancient hunter-gatherer ancestors had an omega-6 to omega-3 ratio that was 1:1 (meaning they were getting about the same amount of omega-6s and omega-3s). But for people eating an average American diet, that ratio is more like 20:1.

This skewed ratio affects weight gain, among other problems. In studies, researchers have shown that when mice were fed a diet high in omega-6s, it resulted in a progressive accumulation of body fat.

Notably, the researchers also found that when the mice were given high omega-6s during pregnancy and thereafter, the weight gain increased across generations. That trend mirrors what we’re seeing in humans, with obesity only getting worse over the decades and emerging earlier and earlier in life.

Having a high omega-6 to omega-3 ratio causes other issues too. Omega-6s are pro-inflammatory, and so, when you eat too many of these fats, it drives chronic low-grade inflammation. As we’ll discuss more in depth below, chronic inflammation both contributes to the progression of obesity – and is one of the major consequences of it as well.

How Omega-3s Influence Metabolic Health

With obesity, researchers are especially focused on central white fat that accumulates deep within the abdominal cavity. This central white fat surrounds vital organs such as the pancreas, intestines, liver, and heart. Its accumulation can lead to a state of chronic inflammation.

Why is chronic inflammation a problem? Well, chronic inflammation is basically the reason why obesity is a health concern. Chronic inflammation leads to a whole host of problems, like heart disease, type 2 diabetes, cancer, and poor immune health.

In white fat, there are several kinds of biomarkers for inflammation, like TNF-alpha, interleukin-6 interleukin-18 and C-reactive protein (CRP). All of these biomarkers increase with weight gain and decrease with weight loss. High levels of these biomarkers are linked to health problems like insulin resistance and metabolic syndrome.

This kind of systemic inflammation is one of the major causes of insulin resistance. This means your body can’t utilize insulin, which is needed to move glucose or sugar into the cell for energy. This in turn produces more insulin. You can start off with having normal blood sugar levels, but eventually, these levels increase and you become pre-diabetic or diabetic.

Now this is where omega-3s come in. Remember how I said that omega-6s are pro-inflammatory? Well, omega-3s are just the opposite. This family of fats reduces inflammation by bringing those biomarkers of inflammation back in check. Take IL-6, as just one example. One 2018 study found that a daily dose of 2500 mg of omega-3s reduced IL-6 levels by 22% in just 8 weeks.

Studies on Omega-3s & Weight Loss

There’s no question that omega-3s are beneficial for combatting the chronic inflammation associated with obesity. But can eating more omega-3s or taking an omega-3 supplement actually help you obtain a healthy body weight?

Here, the jury is still out. A number of animal studies, and some trials with people, have found that fish oil supplementation may protect against obesity and potentially reduce or prevent further weight gain in already obese animals. Some studies have also indicated that omega-3s can support a better body composition and make people feel fuller.

Still other studies of humans have found that omega-3 supplementation didn’t seem to have much of an impact on weight loss. Because of the variety in doses used, target groups, and other varying factors in studies, scientists really don’t have enough data at this time to say if taking fish oil supplements high in omega-3s can aid weight loss specifically.

With that said, several trials have found that taking an omega-3 supplementation as part of a weight loss diet may help dieters get better results. For example, in one study, men who were both on a calorie restricted diet and took supplemental fish oil lost about 2.2 pounds more than men who were not in the fish oil group. Another study similarly found that omega-3s improved abdominal fat mass in obese individuals who were also dieting.

Other Benefits of Omega-3s for Obesity

As anyone who has tried to diet knows, losing weight – and keeping it off long term – isn’t easy. And today, many people question if that narrow focus on the scale even makes sense. As such, some practitioners are now starting to move the focus to reducing the complications of obesity and improving quality of life.

On this front, omega-3s have a lot to offer. Let’s take a look at some of the key areas where omega-3s can make a big difference.

Improving Your Metabolic Profile

Many people who are obese often have an unhealthy metabolic profile. In other words, they often also have high blood pressure, high triglyceride levels, high levels of those inflammatory biomarkers noted above, and insulin resistance. All of these components put you at a greater risk for heart disease, type II diabetes, and many other diseases.

Importantly, not everyone who is obese has a bad metabolic profile. Some people who are classified as obese or overweight can have a health profile, which reduces their risk for disease.

Getting enough omega-3 fatty acids offers one of the best, natural ways to improve your metabolic profile. It’s well accepted that fish oil supplementation combined with a healthy diet can reduce triglyceride levels, if you take an effective daily dose.

It’s also well accepted that omega-3s can improve blood pressure and the levels of inflammation in the body.

Obesity Requires Higher Doses

Importantly though, it’s vital to get enough omega-3 fatty acids for these benefits. Regular fish oil capsules don’t cut it. For triglycerides and high blood pressure, studies show it takes consuming 3000 – 4000 mg of EPA/DHA omega-3s daily to significantly lower levels.

For lowering inflammatory cytokines, at least 2000 mg of EPA/DHA daily are required. And since the daily dose of omega-3s is somewhat influenced by weight, researchers note that higher levels of omega-3s are likely needed for obese individuals.

So what do these doses look like if you want to take an omega-3 supplement? Regular fish oil capsules contain only 300 mg of EPA/DHA, which means you’d be swallowing a good 10 pills per day to get an effective daily dose. Always use liquid omega-3 oil instead of capsules. It is easier to swallow 1 tablespoon of liquid compared to 10 fish oil capsules. But even more important is that our gastrointestinal tract microbiome is heavily involved in fat metabolism and signaling hunger or satiation. Omega-3 oil is a powerful nutrient for the good bacteria we harbor in our mouth all the way through the colon. Using fish oil capsules instead of liquid reduces the area of contact and thus the potency of the oil. Our fresh full spectrum no fish taste liquid Omega Cure or Restore has been used in university studies showing the impact in changing the digestive microbiome to be less inflammatory.  Consuming just 1 vial of Omega Cure Extra Strength per day provides a full 3000 mg of EPA/DHA daily dose in a single, drinkable serving and will make you top 5 % of the population of high body omega-3 content.

Combining Omega-3 Fish Oil with a Healthy Diet


So the conclusion is that combining omega-3 fatty acids with a balanced diet is crucial for a successful weight loss program because it ensures that the body and our microbiome receive all the essential nutrients it needs to function properly. A balanced diet includes a variety of food groups, such as fruits, vegetables, whole grains, lean proteins, and healthy fats, which provide the vitamins, minerals, and energy necessary for optimal health.

When you consume a diet rich in these nutrients, it helps to control hunger and reduce cravings, making it easier to stick to a weight loss plan. Additionally, a balanced diet supports metabolic processes and helps maintain muscle mass, which is important because muscle burns more calories than fat, even at rest.

Incorporating a wide range of foods can also prevent feelings of deprivation, which can often lead to binge eating. Overall, a balanced diet not only enhances the effectiveness of a weight loss program but also promotes overall health and well-being, making it sustainable in the long run.

Anne-Marie Chalmers, MD

Anne-Marie Chalmers, MD

Born and raised in the United States, Dr. Chalmers graduated from Brown University and completed her medical training at the University of Oslo in Norway. Dr. Chalmers practiced medicine for many years, serving both at high-tech hospitals and as a community health worker in rural Norway. Together with Dr. Martinsen, she later co-founded Wellpride LLLP dba Omega3 Innovations and is the joint holder of several patents that facilitate the ingestion of multiple medication combinations. Today, she serves as the president of Omega3 Innovations.

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